Foxa2-dependent hepatic gene regulatory networks depend on physiological state
نویسندگان
چکیده
منابع مشابه
Foxa2-dependent hepatic gene regulatory networks depend on physiological state.
Bile acids are powerful detergents produced by the liver to aid in the absorption of dietary lipids. We recently reported a novel role for Foxa2 in bile acid metabolism. The winged helix transcription factor Foxa2 is required to prevent intrahepatic cholestasis and liver injury in mice fed a cholic acid-enriched diet. Here, we use functional genomics to study how Foxa2 regulates its targets in ...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2009
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.90376.2008